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Why gene therapy for sickle cell is slow to catch on with patients

INSIGHT-Why gene therapy for sickle cell is slow to catch on with patients By Deena Beasley LOS ANGELES, Sept 28 (Reuters) - Student Zoe Davis, 20, was just weeks into her junior year when she landed back in the hospital with severe sickle cell pain earlier this month. She is doing what she can to prevent the crippling attacks in her arms, legs and abdomen that are becoming more frequent.
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Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say

UPDATE 1-Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say EMA raises concerns about deaths in Oxbryta trials Shares of Agios and Fulcrum rise after Pfizer's decision Adds FDA statement in paragraph 4 By Kashish Tandon and Christy Santhosh Sept 26 (Reuters) - Pfizer's PFE.N decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental rivals, Wall Street analysts said.
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Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say

Pfizer's Oxbryta exit may hasten trials of rival experimental sickle cell drugs, analysts say EMA raises concerns about deaths in Oxbryta trials Shares of Agios and Fulcrum rise after Pfizer's decision By Kashish Tandon and Christy Santhosh Sept 26 (Reuters) - Pfizer's PFE.N decision late on Wednesday to withdraw its sickle cell disease treatment due to the risk of death could help speed up trials of new experimental rivals, Wall Street analysts said.
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Generate:Biomedicines Announces Multi-Target Collaboration With Novartis To Discover & Develop Protein Therapeutics With Generative Ai

BRIEF-Generate:Biomedicines Announces Multi-Target Collaboration With Novartis To Discover & Develop Protein Therapeutics With Generative Ai Sept 24 (Reuters) - Novartis AG NOVN.S : GENERATE:BIOMEDICINES: ANNOUNCES MULTI-TARGET COLLABORATION WITH NOVARTIS TO DISCOVER & DEVELOP PROTEIN THERAPEUTICS WITH GENERATIVE AI GENERATE:BIOMEDICINES - POTENTIA
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Sanofi's tolebrutinib drug delays progressive MS by 31% in trial

UPDATE 1-Sanofi's tolebrutinib drug delays progressive MS by 31% in trial Adds details and background throughout By Ludwig Burger FRANKFURT, Sept 20 (Reuters) - Sanofi SASY.PA said on Friday that its multiple sclerosis drug candidate was shown to delay worsening of a progressive form of the disease by 31%, as the French drugmaker eyes a request for approval later this year.
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Swiss trade surplus at CHF 4.578 bln in August

TABLE-Swiss trade surplus at CHF 4.578 bln in August Sept 19 (Reuters) - Switzerland ran a merchandise trade surplus of 4.578 billion Swiss francs in August, the Federal Customs Office said on Thursday. KEY FIGURES (millions of Swiss francs) August 2024 July 2024 Imports 15.912 19.215 Exports 20.491 24.092 Balance 4.578 4.877 The figures exclude precious metals and stones, works of art and antiques.
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Vontobel assesses obesity drugs impact for Swiss insurers, med-tech companies

BUZZ-Vontobel assesses obesity drugs impact for Swiss insurers, med-tech companies ** Vontobel estimates the market potential for obesity drugs in the U.S. to reach a three-digit billion U.S. dollar amount and picks Swiss Re SRENH.S and Ypsomed YPSN.S as the most likely to profit from it ** Among Swiss life insurers, Swiss Re could benefit the most from a rising demand in life and health reinsurance, with a market share of about 15%, as obesity drugs improve life expectancy, it says ** Its posit
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Novartis: New Data In Relapsing MS Reinforce Benefits Of Kesimpta For First-Line And Switch Patients

BRIEF-Novartis: New Data In Relapsing MS Reinforce Benefits Of Kesimpta For First-Line And Switch Patients Sept 18 (Reuters) - Novartis AG NOVN.S : NEW NOVARTIS DATA IN RELAPSING MS REINFORCE BENEFITS OF KESIMPTA® FOR FIRST-LINE AND SWITCH PATIENTS NEARLY 90% OF FIRST-LINE KESIMPTA PATIENTS HAD NO DISABILITY PROGRESSION INDEPENDENT OF RELAPSE ACTI
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Swiss stocks - Factors to watch on September 18

Swiss stocks - Factors to watch on September 18 ZURICH/GDANSK, Sept 18 (Reuters) - Here are some of the main factors that may affect Swiss stocks on Wednesday: MEYER BURGER TECHNOLOGY AG MBTN.S The company said it has planned the streamlining of its group structure and the reduction of its workforce. NOVARTIS AG NOVN.S FDA approves Kisqali to reduce risk of recurrence in people with HR+/HER2- early breast cancer.
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Novartis Says FDA Approves Kisqali To Reduce Risk Of Recurrence In People With HR+/Early Breast Cancer

BRIEF-Novartis Says FDA Approves Kisqali To Reduce Risk Of Recurrence In People With HR+/HER2- Early Breast Cancer Sept 17 (Reuters) - Novartis AG NOVN.S : FDA APPROVES NOVARTIS KISQALI® TO REDUCE RISK OF RECURRENCE IN PEOPLE WITH HR+/HER2- EARLY BREAST CANCER Source text for Eikon: ID:nGNEVXqGz Further company coverage: NOVN.S
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Novartis Novartis Kisqali® Shows Deepening Benefit In New Analysis, Reducing Risk Of Recurrence By 28.5% In A Broad Population Of Patients With Early Breast Cancer

BRIEF-Novartis Novartis Kisqali® Shows Deepening Benefit In New Analysis, Reducing Risk Of Recurrence By 28.5% In A Broad Population Of Patients With Early Breast Cancer Novartis AG NOVN.S : : NOVARTIS KISQALI® SHOWS DEEPENING BENEFIT IN NEW ANALYSIS, REDUCING RISK OF RECURRENCE BY 28.5% IN A BROAD POPULATION OF PATIENTS WITH EARLY BREAST CANCER
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US FDA approves injectable version of Roche's multiple sclerosis therapy

UPDATE 1-US FDA approves injectable version of Roche's multiple sclerosis therapy Adds price and availability in paragraph 4 Sept 13 (Reuters) - The U.S. Food and Drug Administration on Friday approved Roche's ROG.S under-the-skin injection to treat patients with multiple sclerosis. The subcutaneous or under-the-skin therapy called Ocrevus Zunovo has the potential to expand treatment options to centers unable to administer the IV version.
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US FDA approves injectable version of Roche's multiple sclerosis therapy

US FDA approves injectable version of Roche's multiple sclerosis therapy Sept 13 (Reuters) - The U.S. Food and Drug Administration on Friday approved Roche's ROG.S under-the-skin injection to treat patients with multiple sclerosis. The subcutaneous or under-the-skin therapy called Ocrevus Zunovo has the potential to expand treatment options to centers unable to administer the IV version.
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US FDA approves injectable version of Roche's multiple sclerosis therapy

UPDATE 1-US FDA approves injectable version of Roche's multiple sclerosis therapy Adds background throughout Sept 12 (Reuters) - The U.S. Food and Drug Administration on Thursday approved Roche's ROG.S under-the-skin injection to treat patients with multiple sclerosis. The therapy is already approved as an infusion or IV therapy for multiple sclerosis, which is given twice a year, under the brand name Ocrevus.
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US FDA approves injectable version of Roche's multiple sclerosis therapy

UPDATE 1-US FDA approves injectable version of Roche's multiple sclerosis therapy Adds background throughout Sept 12 (Reuters) - The U.S. Food and Drug Administration on Thursday approved Roche's ROG.S under-the-skin injection to treat patients with multiple sclerosis. The therapy is already approved as an infusion or IV therapy for multiple sclerosis, which is given twice a year, under the brand name Ocrevus.
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BMW, Legrand, Sodexo

EUROPE RESEARCH ROUNDUP- BMW, Legrand, Sodexo Sept 11 (Reuters) - Securities analysts revised their ratings and price targets on several European companies, including BMW, Legrand and Sodexo, on Wednesday. HIGHLIGHTS * BMW BMWG.DE : HSBC cuts target price to EUR 85 from EUR 109 * Kion Group AG KGX.DE : JP Morgan raises to overweight from neutral * Legrand LEGD.PA : JP Morgan raises to overweight from neutral * Phoenix PHNX.L : Peel Hunt cuts target price to 650p from 690p * Sodexo EXHO.PA : JP M
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Relay Therapeutics' combo therapy cuts breast cancer progression in early study

UPDATE 1-Relay Therapeutics' combo therapy cuts breast cancer progression in early study Adds shares in paragraph 1 By Mariam Sunny and Sneha S K Sept 9 (Reuters) - Relay Therapeutics RLAY.O said on Monday interim data from an early-stage study of its combination drug for breast cancer showed it meaningfully extended the time patients lived without the disease worsening, sending shares surging about 37% in early trading.
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Relay Therapeutics' combo therapy for breast cancer cuts disease progression in early study

Relay Therapeutics' combo therapy for breast cancer cuts disease progression in early study By Mariam Sunny and Sneha S K Sept 9 (Reuters) - Relay Therapeutics RLAY.O said on Monday interim data from an early-stage study of its experimental combination treatment for breast cancer showed it meaningfully extended the time patients lived without their disease worsening.
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Judge won't block Maryland law mandating discounts for hospitals' outside pharmacies

Judge won't block Maryland law mandating discounts for hospitals' outside pharmacies By Brendan Pierson Sept 6 (Reuters) - The largest U.S. drug industry group and several drug companies have lost a bid to block a Maryland law requiring drugmakers to offer discounts on drugs dispensed by third-party pharmacies that contract with hospitals and clinics serving low-income populations.
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U.S. STOCKS MarketAxess, Perpetua Resources, Sotera Health

BUZZ-U.S. STOCKS ON THE MOVE-MarketAxess, Perpetua Resources, Sotera Health Eikon search string for individual stock moves: STXBZ The Day Ahead newsletter: https://refini.tv/3LI4BU7 The Morning News Call newsletter: https://refini.tv/3dKUyB8 Wall Street's three main indexes slipped in choppy trading on Thursday as a short-lived boost from a services activity survey fizzled out ahead of an upcoming employment report.
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